Catalyst: and solvent-free synthesis of imidazo[1,2-a]pyridines

AUTOR(ES)

Zhu, Dong-Jian, Chen, Jiu-Xi, Liu, Miao-Chang, Ding, Jin-Chang, Wu, Hua-Yue

FONTE

Journal of the Brazilian Chemical Society

DATA DE PUBLICAÇÃO

2009

RESUMO

Um método altamente eficiente e simples foi descrito para a síntese de imidazo[1,2-a]piridinas pela condensação de α-halocetonas (ArCOCHXR², Ar = C6H5, 4-MeOC6H4, 4-ClC6H4, 2,4-Cl2C6H3; X = Br, Cl; R² = H, CH3) com 2-aminopiridinas, apresentando rendimentos entre bons a excelentes sem a necessidade de adição de catalisador e solvente.

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