Carcinogen-induced trans activation of gene expression.
AUTOR(ES)
Kleinberger, T
RESUMO
We report a new mechanism of carcinogen action by which the expression of several genes was concomitantly enhanced. This mechanism involved the altered activity of cellular factors which modulate the expression of genes under their control. The increased expression was regulated at least in part on the transcriptional level and did not require amplification of the overexpressed genes. This phenomenon was transient; it was apparent as early as 24 h after carcinogen treatment and declined a few days later.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=363284Documentos Relacionados
- Analysis of the rearrangements associated with carcinogen-induced activation of the hamster thymidine kinase gene.
- Carcinogen-induced frameshift mutagenesis in repetitive sequences.
- Carcinogen-Induced Chromosomal Breakage Decreased by Antioxidants
- Expression of a fms-related oncogene in carcinogen-induced neoplastic epithelial cells.
- Structural analysis of a carcinogen-induced genomic rearrangement event.