BIODEGRADABLE SODIUM CARBOXYMETHYL CELLULOSE MEMBRANES CONTAINING MELALEUCA ESSENTIAL OILS FOR WOUND CARE MATERIAL
AUTOR(ES)
Soares, Silvane Holanda; Peixoto, Hugo Cavalcante; Prudencio, Edlene Ribeiro; Luchese, Rosa Helena; Araújo, Robson; Moreira, Ana Paula Duarte; Araújo, Leonardo Sales; Rosado, Luiz Henrique Guerreiro; Cunha, Rommel Sauerbronn da; Castro, Rosane Nora; Oliveira, Renata Nunes
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2022
RESUMO
NaCMC is a biocompatible polymer that can be crosslinked with citric acid to form a gel matrix. Melaleuca oils have antimicrobial and anti-inflammatory properties with potential for wound healing. The goal of this work was to investigate the characteristics of NaCMC-Melaleuca oils gels. The gels were characterized by FTIR, TGA, mechanical analysis, and in vitro swelling and S. aureus inhibition tests. The oils were characterized using chromatography, presenting high values of (1,8-cineol/terpinen-4-ol), and evaluated for confirmation of their effect against S. aureus. The samples showed physical interactions between NaCMC, citric acid and the Melaleuca oils. Erosion in saline solution was higher in the gels with oils, attributable to interference with crosslinking. The membranes presented high contribution of relaxation mechanism and low contribution of Fickian diffusion regarding the swelling ability. The presence of the oils increased thermal stability and diminished gel fraction and mechanical properties, indicating that the oils interact with the matrix anchoring the chains. Although melaleuca oils themselves were active against S. aureus and CA was responsible for the NaCMC hydrogels activity, the incorporation of melaleuca oils in NaCMC gels was not reported previously. This report indicates that NaCMC hydrogel may be a proper matrix for essential oils incorporation.
Documentos Relacionados
- Viscoelastic evaluation of topical creams containing microcrystalline cellulose/sodium carboxymethyl cellulose as stabilizer
- Dexamethasone and sodium carboxymethyl cellulose prevent postoperative intraperitoneal adhesions in rats
- Role of Sodium Carboxymethyl Cellulose and Hydroxyethyl Starch in Hematopoietic Cell Line Cultures
- Carboxymethyl Cellulose Decomposition by Intestinal Bacteria of Cockroaches
- Bacterial Cellulose/Collagen Hydrogel for Wound Healing