Baixas concentrações séricas de 25-hidroxivitamina D em crianças e adolescentes com lúpus eritematoso sistêmico. / Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

29/06/2011

RESUMO

Objective: to evaluate the levels of 25-hydroxivitamin-D (25(OH)D) in children and adolescents with Systemic Lupus Erythematosus (Juvenile SLE [JSLE]) and to associate them with disease duration and activity, use of medications (chloroquine and glucocorticoids), vitamin D intake, levels of calcium, phosphorus and alkaline phosphatase and bone mineral density. Methods: through a cross-sectional study 30 children and adolescents with SLE were evaluated and compared to 30 healthy individuals age and gender matched. Assessment of clinical status, disease activity, anthropometry, laboratory markers and bone mineral density were performed. Results: of the 30 patients included in the study, 25 (83.3%) were female, 16 (53.3%) caucasians, mean of age of 13.7 years. The mean of age at diagnosis was 10.5 years and the mean of disease duration was 3.4 years. The mean levels of calcium, albumin and alkaline phosphatase were significant lower in the patients with JSLE compared with controls (p<0.001, p=0.006 and p<0.001, respectively). Twenty-nine patients (97%) and 23 controls (77%) had 25(OH)D levels lower than 32 ng/mL with significantly difference between them (p<0.001). Fifteen patients (50%) had vitamin D levels <20 ng/ml and 14 between 20 and 32 ng/ml. However those values were not associated to greater disease activity, higher levels of parathormone, medications or bone mineral density. Vitamin D levels were not different related to ethnic group (p=0.083), body mass index (p=0.955), height to age (p=0.650) and pubertal stage (p=0.524). Conclusions: we observed insufficient serum concentrations of 25(OH)D in patients with JSLE significantly more frequently than in controls, however with no association with disease activity, higher levels of parathormone, use of medications or bone mineral density alterations.

ASSUNTO(S)

juvenile systemic lupus erythematosus lúpus eritematoso sistêmico vitamina d cálcio paratormônio crianças e adolescentes pediatria vitamin d calcium bone metabolism parathormone

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