Avaliação das atividades analgesica e antiinflamatoria da fração hexanica Agave sisalana / Evaluation of activities analgesic and anti-inflammatory of hexanic fraction of Agave sisalana

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Pain is defined as complex and vague sensation that involves several factors such as life style and environment. Many times pain is a result of an inflammatory process. The inflammation an imune system response to different kind of stimulus, microorganisms, tissue injuries, miogenic stimulus or even cirurgic traumas, which release several endogens mediators. Receiving the stimulus, diferents enzymes as phospholipase and ciclogenasis, lead to inflammatory mediators (prostaglandins, citocins and leukotrienes) which continuity the inflammatory cascade, many times in an exarcebate manner, described by the five cardinals signs: Heat, redness, swelling, pain and loss of function. Inflammation Treatment the first choice in medicine are non steroidal antiinflammatory drugs (NSAIDS) that acts in inhibition of COX-2. However, the use of NSAIDS can bring peptic ulcers or kidney failure and cardiac problems in selective COX inhibitors. Chronic inflammation uses Glucocorticoids therapy that are powerfull drugs, but they provoque systemics side effects: as hypoglicemy, nervous system activity and immune system depression. The use of active compounds present in plants is a way to inflammatory controll, among them there are plants of Agavaceae family mainly Agave genus, such as Agave sisalana which is rich in steroidals saponins. Saponins are a secundary metabolic class that present several therapeutic functions, with a large comercial and pharmacological interest. These compounds present steroidal nucleus involved by sugar chains called algycone or sapogenins. From the Agave sisalana was taken Agave sisalana hexanic fraction (FHAS) that had its therapeutic potential evaluated in differents inflammatory, algesic and toxicity tests. FHAS showed significative responses for acute inflammatory models with antiedematogenic activity as xylene ear edema and carrageenan hind paw edema. FHAS also presents significative results chronic models like granuloma cotton pellet, which evaluate cell infiltration. The values gotten on cotton pellet were confirmed with pleurisy model, where there were reduction of cellular infiltrate. FHAS showed antinociceptive potential in algesic tests, with a smaller action than standard medicine, which indicates that the action mechanisms does not acts on opioid receptors in analgesic models. In connection to toxicity, FHAS does not present increase of plasmatics proteins, and animal weight evaluation none of FHAS doses showed significative effects considering weight up of animals. In case of positive control GC that indicates absence of side effects such GC. Throughout data analyses, the antiinflammatory and analgesic action founded is tempted by sapogenins presence on FHAS. These results need new evaluation to explain the antiinflammatory action mechanisms bringing new perspectives of Agave sisalana medical use

ASSUNTO(S)

inflammation sapogeninas sisal inflamação sisal glucocorticoids glicocorticoides analgesia analgesia sapogenins

ACESSO AO ARTIGO

Documentos Relacionados