AVALIAÇÃO DA SENSIBILIDADE DO BARORREFLEXO EM MODELO EXPERIMENTAL DE HIPERCOLESTEROLEMIA CO-EXISTENTE COM HIPERTENSÃO RENAL

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Hypercholesterolemia (HC) and arterial hypertension (AH) are both major risk factors for the development and progression of atherosclerotic heart disease, and their co-existence has been associated with an increased incidence of cardiac events in clinical studies. The baroreflex sensitivity is a very important index in the prognosis of various cardiovascular diseases. Thus, the aim of this study is evaluate the baroreflex sensitivity in simultaneously hypercholesterolemic and hypertensive rats. Wistar and Fisher rats were used. The animals were submitted to the hipercolesterolemic (Hyper) (1% cholesterol, 25% soy oil) or control (Cont) diet 30 days before and 30 days after the 2K1C (2 kidney, 1 clip) para produção da hipertensão renal or fictitious surgery (Sham). Com o objetivo de obter níveis maiores de colesterol sérico, sham rats (Fisher) were submitted to the hyper diet supplemented with 0,3% of sodium deoxycholate (SD). The baroreflex sensitivity was determined by alterations on arterial pressure induced by intravenous bolus injections of increasing doses of phenylephrine and sodium nitroprusside to evaluate bradycardic and tachycardic components, respectively. The Hyper diet didnt increased the serum cholesterol levels in Wistar (45,918,9 mg/dL, 2R1Chiper e 74,613,5 mg/dL, ShamHiper) when compared to control animals to sympathetic hyperactivity and mainly to the reduction of the vagal efferent component, once the alterations are more evident on the increasing than the decreasing of arterial pressure. Our data also suggest that HC do not affect the baroreflex sensitivity, decreased due to renovascular hypertension, in the organism where HC and AH co-exist.

ASSUNTO(S)

bioquimica 1. hipercolesterolemia - teses. 2. hipertensão renal - teses. 3. taquicardia - teses. 4. pressão arterial - teses.

ACESSO AO ARTIGO

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