Avaliação da população de linfócitos CD4+ com potencial regulador em pacientes com Imunodeficiência Comum Variável e Deficiência Seletiva de Imunoglobulina A. / Evaluation of the population of CD4+ lymphocytes in patients with Common Variable Immunodeficiency and Selective Immunoglobulin A Deficiency.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

Common Variable Immunodeficiency (CVID) and Selective Immunoglobulin A deficiency (IgAD) are the humoral primary immunodeficiencies with the highest incidence in the population. Both diseases are characterized by the absence or significant reduction of serum immunoglobulins. Although several immunological abnormalities have been associated with these diseases, no unifying hypothesis regarding the molecular basis of CVID and IgAD have been proposed to date, and the only defect common to all patients is the failure in differentiation of B cells into plasma cells and consequent secretion of antibodies. Due to the high incidence of autoimmunity and allergy in patients with CVID and IgAD, in the present work we analyzed by flow cytometry the population of CD4+ lymphocytes with regulatory potential in these patients to assess whether possible quantitative or functional defects in this regulatory population could explain the high incidence of autoimmune diseases or allergic reactions associated with these immunodeficiencies.

ASSUNTO(S)

células t reguladoras doenças imunológicas atopy auto-imunidade immunological diseases atopias autoimmunity common variable immunodeficiency hereditariedade deficiência seletiva de imunoglobulina a (diga) linfócitos t foxp3 immunoglobulins imunodeficiência comum variável citometria de fluxo flow cytometry regulatory t cells t lymphocytes foxp3 imunoglobulinas heredity selective immunoglobulin a deficiency (igad)

ACESSO AO ARTIGO

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