Avaliação da classificação de gravidade e da resposta ao tratamento contra leishmaniose visceral grave em crianças em hospital de referência em Palmas, Tocantins

AUTOR(ES)

Erika Gonçalves Afonso Maués

DATA DE PUBLICAÇÃO

2008

RESUMO

The present consists of a descriptive study with a retrospective and a prospective part, with the aim to consider the classification of the serious forms and the risk for death as described in the Manual of Visceral Leishmaniasis (VL) (2005), of Health Ministery, and the treatment results using Glucantime and anphotericin B derivates, in children with VL seen in a reference hospital in Palmas, Tocantins, from January of 2005 to October of 2007. The samping consisted of 34 patients in the retrospective study, with 64,7% classified as serious forms and treated with N-metilglucamina antimoniate (Glucantime) and 19 children of the prospective study, with 78,9% classified as serious forms and treated with anphotericin B derivates. Children between 1 and 5 years and of female sex were more affected in both groups. In the retrospective study, 79,4% of the patients were from Palmas while in the prospective one, 57,9 % came from other cities. The fever and the parlor were most frequently observed, but there was no significant difference between the groups of treatment. The criteria that contributed for clinical seriousness were: secondary bacterial infection, toxemia, serious anemia, coagulation disturbance, age below 6 months and jaundice. The principal seriousness criteria found in the two groups was infection, specially pneumonia in 68,1 % of the Glucantime group and in 93,4 % of the patients treated with anphotericin B. There was no significant difference between the proportions of discharges. It was not possible to consider the risks criteria for death because of the small samping and the equal proportion of deaths between the two groups. Studies will be necessary to validate the risks criteria for death and consider the impact of using more potent leishmanicidal drugs.

ASSUNTO(S)

medicina leishmaniose visceral grave em crianças

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