Avaliação da biocompatibilidade "in vitro" e "in vivo" de ligas metálicas de titânio para aplicação odontológica / "In vitro" and "in vivo" biocompatibility evaluation of Ti alloys for odontological applications

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Biomaterial applications have increased in the last decade, since bone diseases, injury from accidents have reached an increasing number of people. In dentistic, biomaterials have also large use as to estetic application as well to recuperate the function. New biomaterials have been studied in order to get better mechanical properties allowing better performance of the biomedical device. Biocompatibility studies are part of the validation processes and in vivo testes and in vitro testes are carried out. The present work evaluated biocompatibility of Ti alloys through: haemocompatibility, cytotoxicity, systemic toxicity and washed peritoneal tests. Those tests were performed in rats which were in contact with extracts made from artificial salive plus NaF (low concentrations) with Ti-6Al-4V alloy (control test) and Ti-10Mo (under test). Alloy under test and its extracts shown biocompatible behavior suggesting for odontological applications.

ASSUNTO(S)

biocompatibilidade in vitro e in vivo biomateriais biomaterials citotoxicidade citotoxicity haemocompatibility hemocompatibilidade systemic toxicity biocompatibility in vitro and in vivo toxicidade sistêmica

ACESSO AO ARTIGO

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