Avaliação clinica, histologica e imunoistoquimica de GVHDc em glandulas salivares menores

AUTOR(ES)
DATA DE PUBLICAÇÃO

2003

RESUMO

The major cause of morbidity and mortality in patients undergoing allogeneic bone marrow transplantation is graft-versus-host disease (GVHD). The clinical and histological manifestation of oral mucosa can precede other organ involvement in the GVHDc. The aim of our study was to evaluate the predictive risk factors to GVHDc, the histological and immunohistochemical differences between patients with or without GVHDc, as well as to evaluate the immunophenotype of the inflammatory cells in oral mucosa and labial salivary gland. Twenty-five patients who had GVHDc (experimental-group) and 16 patients who had not GVHOc were seected. The data patient, gender, underlying disease, type of transplantation, donor gender, compatibility of the system ABO and HLA, infection diseases, previous GVHDa, organ involved in the GVHOc, were obtained frem the clinical records. The slides were firstly examined in H&E. Immunohistochemical analyses included the following antibodies CD68, CD45, CD4, CD8, CD20. The age of the patients (oldest), type of transplantation and infection disease were found risk factors to GVHDc Hydropic degeneration of the basal cells, apoptotic bodies, Iymphocytic infiltration, and focal or total clivage between epithelial and connective tissue were histological features that could be used to differentiate GVHDc frem chemotherapy effects on oral mucosa. In the labial salivary glands the Iymphocytic infiltration, acinar 1055and fibresis were the main alteration. The predominant cells in GVHDc were CD8 T cells in epithelium, connective tissue as much as in salivary glands

ASSUNTO(S)

histopatologia mucosa bucal

ACESSO AO ARTIGO

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