Autoimmune antibody (IgG Kansas) against the fibrin stabilizing factor (factor XIII) system.
AUTOR(ES)
Lorand, L
RESUMO
Serum from a patient who died from massive hemorrhage within 4 months after onset of an acquired bleeding disorder at age 85 contained a potent inhibitor of fibrin stabilization. Other parameters of coagulation and fibrinolysis and his bleeding time were within normal limits. The inhibitor was shown to be an IgG with kappa light chains (IgG Kansas); its specific target was the factor XIII system itself. Although IgG Kansas combined with the virgin [ab] form of the zymogen, it did not block the thrombin-catalyzed conversion to [a'b]. However, IgG Kansas prevented the subsequent Ca2+-mediated activation of [a'b] to a + b, where a denotes the catalytically competent factor XIIIa species. IgG Kansas, in contrast to a previously studied autoimmune antibody from a similar bleeding disorder (IgG Warsaw), could also inhibit the transamidating activity of the preactivated a enzyme.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=279518Documentos Relacionados
- Antibody synthesis within the central nervous system: comparisons of CSF IgG indices and electrophoresis
- Transfer of functional immunoglobulin G (IgG) antibody into the gastrointestinal tract accounts for IgG clearance in calves.
- Urinary IgG antibody against mixed heat-killed coliform antigen and lipopolysaccharide core antigen.
- Detection of IgG rheumatoid factor by concanavalin A treatment and complement fixation with IgG rheumatoid factor.
- Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM