Atypical toxin variant of Clostridium botulinum type B associated with infant botulism.
AUTOR(ES)
Hatheway, C L
RESUMO
An atypical toxin variant of Clostridium botulinum (strain 657) was isolated from the feces of a 6-week-old female infant whose symptoms and clinical history were consistent with infant botulism. Toxin detected in the feces and the toxin produced by isolates from the feces and from two rectal swabs could be neutralized by type B botulinal antitoxin only at very high ratios of of antitoxin to toxin in the neutralization mixture. One international unit of type B antitoxin neutralized only about 10 lethal doses of 657 toxin as compared with approximately 10,000 lethal doses of conventional type B toxin from the Beans strain. Antitoxin prepared against 657 toxin was 10 times more effective against the conventional toxin than against the homologous toxin. Toxoid-antitoxin-binding studies indicate that both 657 toxin and type B toxin are heterogeneous and that both toxins may contain the same molecular variants, but that the proportions of the variants are different in each.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=274006Documentos Relacionados
- Emergence of Clostridium botulinum type B-like nontoxigenic organisms in a patient with type B infant botulism.
- Quantitation of Clostridium botulinum organisms and toxin in the feces of an infant with botulism.
- Quantities of Clostridium botulinum organisms and toxin in feces and presence of Clostridium botulinum toxin in the serum of an infant with botulism.
- Characterization of Clostridium botulinum Type B Neurotoxin Associated with Infant Botulism in Japan
- Isolation of an organism resembling Clostridium barati which produces type F botulinal toxin from an infant with botulism.