Atividade de substâncias isoladas de liquens sobre formas promastigotas de Leishmania (L.) amazonensis e Leishmania (V.) braziliensis.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Leishmaniasis is a parasitary and endemic infection caused by Leishmania parasites. About 1,5 million people are attacked for cutaneous leishmaniasis, reaching 88 countries, being of obligatory notification in only 30 of them. Presented in all American continent and has Brazil the country with the biggest prevalence of cases. This study it was carried through with nineteen extracted substances of lichens. It was tested in vitro to evaluate the leishmanicida action on forms promastigote of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis.The anti-leishmania activity was compared with the activity of Miltefosine drug. Substances of liches from six species tested (Parmotrema tinctorum, Parmotrema dilatatum, Cladonia verticillaris, confused Cladina, Ramalina peranceps and Parmotrema lichexanthonicum) showed activity in concentrations ranging from 100 to 12,5 μg/mL. Among the tested substances of liches, the orselinato of n-pentila showed the best activity up to the concentrations of 12,5 μg/mL for Leishmania (Viannia) braziliensis and the concentrations of 50 μg/mL for Leishmania (Leishmania) amazonensis. The results obtained are promissing and the substances of lichens may represents a source of active substances against Lesihmnia ssp.

ASSUNTO(S)

promastigotas leishmania (l.) amazonensis leishmania (leishmania) amazonensis leishmania (v.) braziliensis promatigotes leishmania (viannia) braziliensis substances of liches susbtâncias liquênicas ciencias da saude

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