Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans
AUTOR(ES)
Peralta-Leal, Valeria, Leal-Ugarte, Evelia, Meza-Espinoza, Juan P., Dávalos-Rodríguez, Ingrid P., Bocanegra-Alonso, Anabel, Acosta-González, Rosa I., Gonzales, Enrique, Nair, Saraswathy, Durán-González, Jorge
FONTE
Genetics and Molecular Biology
DATA DE PUBLICAÇÃO
26/07/2012
RESUMO
The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy- Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development of T2DM in this Mexican population sample (p = 0.12). Nevertheless, logistic regression analysis of the L allele and increased BMI disclosed an association, after adjusting for age, sex and T2DM (p = 0.02, OR 1.74, 95% CI: 1.079-2.808).
Documentos Relacionados
- Polymorphism of Serotonin Transporter SLC6A4 (5-HTTLPR) Gene in Cheilitis Angularis Patients
- Allelic Heterogeneity at the Serotonin Transporter Locus (SLC6A4) Confers Susceptibility to Autism and Rigid-Compulsive Behaviors
- Genetic analysis of the ELOVL6 gene polymorphism associated with type 2 diabetes mellitus
- Lack of association between the serotonin transporter promoter polymorphism (5-HTTLPR) and panic disorder : a systematic review and meta-analysis
- Transtorno obsessivo-compulsivo e 5-HTTLPR