ASSOCIAÇÃO DO POLIMORFISMO INSERÇÃO/DELEÇÃO DO GENE DIPEPTILCARBOXIPEPTIDASE (DCP1) COM FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES EM ESCOLARES.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

A descriptive cross-sectional study was accomplished on the associations between risk factors for CVD (anthropometric, biochemical and clinical) and the insertion/deletion polymorphism (In/Del) of the gene of the angiotensin-converting enzyme (DCP1- dipeptidylcarboxipeptidase 1) in schoolchildren. The In/Del DCP1 polymorphism was determined from DNA obtained of 773 participants by the amplification for polimerase chain reaction (PCR). The children were grouped according to the genotype (DD, homozygous for deletion; ID, heterozygous and II, homozygous for insertion) and continuous variables (weigh, height, BMI, waist circumference, % body fat, glycemia, total cholesterol, HDL-c, LDL-c, triglycerides and blood pressure) were compared among the genotypes groups considering the total sample and after stratifying for sex and for sexual maturation. It was observed that the glycemia levels were statistically higher in children DD (83,57 mg/dl) than in children II (81,81 m g/dl); similar result was observed when evaluating boys in the post-puberty stage. The boys DD also presented % body fat statistically higher than boys ID. Additionally, boys DD presented lower levels of the diastolic blood pressure (60,50 mmHg) than boys ID (61,56 mmHg) followed by boys II (63,21 mmHg); similar behavior was found for all children in the pubertal stage. When boys stratified by stadium of sexual maturation were evaluated, associations were observed only at the pre-pubertal and pubertal stages. In the prepubertal stage, besides maintaining the behavior for the % body fat, boys DD presented higher TG (78,73 mg/dl) and BMI (17,49 Kg/m2) than boys ID (16,31 mg/dl and 16,31 Kg/m2, respectively); and in the pubertal stage, the behavior of the blood pressure altered, with boys DD presenting higher systolic blood pressure (113,8 mmHg) than boys ID (107,1 mmHg). For the girls, associations between risk factors and the polymorphism were found only after categorizing for sexual maturation stage. It was observed that in the pubertal phase, girls DD presented phenotype associated to lower risk for cardiovascular disease than girls ID or II. Our results indicate an interaction between the In/Del polymorphism of the DCP1 gene and hormonal factors in the determination of phenotypes associated to the risk of cardiovascular disease in children and adolescents.

ASSUNTO(S)

sistema cardiovascular biologia molecular crianças doenças epidemiologia molecular hipertensão

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