Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection.

AUTOR(ES)

Harris, S C

RESUMO

A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 micrograms/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.

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