Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits

AUTOR(ES)

Oliveira, Flávio Augusto de Souza, Passarini, Guilherme Matos, Medeiros, Daniel Sol Sol de, Santos, Ana Paula de Azevedo, Fialho, Saara Neri, Gouveia, Aurileya de Jesus, Latorre, Marcinete, Freitag, Elci Marlei, Medeiros, Patrícia Soares de Maria de, Teles, Carolina Bioni Garcia, Facundo, Valdir Alves

FONTE

Rev. Soc. Bras. Med. Trop.

DATA DE PUBLICAÇÃO

2018-06

RESUMO

Abstract INTRODUCTION This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis. METHODS The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured. RESULTS Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity. CONCLUSIONS The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.

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