Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.

AUTOR(ES)

Klepser, M E

RESUMO

Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.

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