Antidepressant effects of standardized extract of Commiphora mukul Engl. in olfactory bulbectomized rats
AUTOR(ES)
Kalshetti, Padmaja Bhimashankar, Alluri, Ramesh, Thakurdesai, Prasad Arvind
FONTE
Braz. arch. biol. technol.
DATA DE PUBLICAÇÃO
2015-02
RESUMO
The objective of this work was to evaluate the effects of standardized hydroalcholic extract of Commiphora mukul (HECM) in animal model of chronic stress medicated depression, namely olfactory bulbectomy (OBX) model in rats. Effects of 14-day (subacute) oral pretreatment of HECM (50, 100 and 200 mg/kg) were evaluated on depression and stress related parameters on OBX rats. Separate groups for sham control, OBX control and positive controls namely imipramine (20 mg/kg), fluoxetine (30 mg/kg) and desipramine (15 mg/kg) were also maintained. Behavioral and physiological parameters in open field and elevated plus maze were recorded. HECM showed dose-dependent reversal of OBX-induced physiological effects such as reduction of body weight, body temperature, heart rate and serum sodium concentration. HECM also showed reversal effects on OBX induced food intake increase and hyperactivity in open field and elevated plus maze paradigm. In conclusion, HECM demonstrated restorative effects in OBX induced depression model in rats probably due to stress reliving mechanisms.
Documentos Relacionados
- Efeitos do extrato aquoso da raiz de Ouratea semiserrata (Mart.) Engl. (Ochnaceae) sobre os testículos de camundongos suíços adultos
- Study on the developmental toxicity of a standardized extract of Orthosiphon stamineus in rats
- Flavonóides, benzofenonas e um novo eufano de Clusia columnaris Engl.
- Antidepressant effects of Kai-Xin-San in fluoxetine-resistant depression rats
- Potencial alelopático de folhas e cascas de Esenbeckia leiocarpa Engl. (Rutaceae)