Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis
AUTOR(ES)
El-Gabalawy, Hani S
FONTE
BioMed Central
RESUMO
Anti-Sa antibodies are detected in the serum of 20–47% of patients with rheumatoid arthritis. These antibodies have a high degree of specificity for the disease, and appear to identify a subset of early rheumatoid arthritis patients destined to have aggressive and destructive disease. It has recently been confirmed that anti-Sa antibodies are directed to citrullinated vimentin, thus placing them in the anti-citrulline family of autoantibodies. The Sa antigen has previously been shown to be present in synovium. This, along with the demonstration of citrullinated proteins in rheumatoid synovium, suggests that anti-Sa antibodies may play a pathogenetic role in the initiation and/or persistence of rheumatoid synovitis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=400444Documentos Relacionados
- Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin
- Antikeratin antibodies: diagnostic and prognostic markers for early rheumatoid arthritis.
- Prognostic significance of paraproteinaemia in rheumatoid arthritis.
- Significance of laminar antikeratin antibodies to rat oesophagus in rheumatoid arthritis.
- Rheumatoid Arthritis: Pathogenetic Mechanisms and Consequences in Therapeutics
