ANÁLISE MICROSCÓPICA DAS CÉLULAS CILIADAS EXTERNAS NO USO DA GENTAMICINA

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

The anticipated identification of auditory disturbances makes possible the intervention in the risk period and also ideal to stimulate language and audition. Infant ototoxicity is a very controversial subject. Several cases of ototoxicity in children using aminoglicosides antibiotics have been reported. The main pediatric groups that receive aminoglicosides antibiotics are neonates with serious infections in the neonates intensive care unit (UTI). Goals: to verify the functional alterations to the external ciliary cells of the cochlea to therapeutical schemas used for the treatment of infections in the neonatal period. Way of Study: Experimental. Material and Method: 26 albino guinea pigs have been studied through otoacustic emissions per product of distortion, which are previous and posterior to the application of gentamicin. Results: The functional condition of all external ciliary cells, which have been studied by otoacustic emissions per product of distortion were preserved in all the assessments. Conclusion: In this experiment no changes were observed in the functions of external ciliary cells of albino guinea-pigs being treated with gentamicin in doses of 4 mg / kg / day and 2.5 mg / kg / day for every 12 hours in 10 and 14 days.

ASSUNTO(S)

gentamicin newborn toxicidade drug toxicity neonatos gentamicina fonoaudiologia hearing audição

ACESSO AO ARTIGO

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