Análise dos marcadores bioquímicos fosfatase alcalina óssea específica e deoxipiridinolina no metabolismo ósseo de recém-nascidos pré-termo submetidos a fisioterapia motora

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

2010

RESUMO

Introduction: Preterm infants need minimal handling in order to protect them from stress, resulting in bone resorption and demineralization. Objetives: To evaluate bone formation in newborn preterm infants before and after a physical therapy protocol, by means of biochemical markers bone-specific alkaline phosphatase (BAP) and urinary deoxypyridinoline (DPD). Method: Randomized controlled clinical trials included 30 newborn preterm infants with gestational ages of 35 weeks or less and appropriate weight for gestational age were randomized into control group (CG) and physiotherapy group (PG). Physical therapy protocol consisted of 15 minutes of daily passive movements with gentle joint compression, five days a week. Daily data were obtained on feeding and body weight. BAP and DPD were collected before and after intervention in both groups. ANCOVA test was performed to compare the means of both groups. Results: At baseline, gestational age and corrected gestational age, birth weight and gender were similar between groups. The supply of nutrients, time of use of Total Parenteral Nutrition and mechanical ventilation were similar among groups. The increase of BAP levels for PG was 22.44 ± 3.49 U/L, whereas CG presented an increase of 2.87 ± 3.99 U/L (p= 0.003). There was a reduction on DPD levels for PG of 28.21 ± 11.05 nmol/mmol, and an increase of 49.95 ± 11.05 nmol/mmol (p<0.001) in GC. Conclusion: Physiotherapy intervention results in beneficial effects to bone metabolism of preterm infants and should be included in the standard care of preterm infants.

ASSUNTO(S)

preterm doenças ósseas metabólicas prematuro bone markers physiotherapy fisioterapia marcadores biológicos osteopenia

ACESSO AO ARTIGO

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