Análise da expressão da metaloproteinase de matriz do tipo 9 em esfregaços cérvico-vaginais: um estudo citopatológico / Evaluation of the expression of matrix metalloproteinase type 9 in cervicovaginal smears: a cytological study

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

28/07/2011

RESUMO

The Human Papillomavirus (HPV) are epitheliotropic viruses from family Papillomaviridae, which cause skin or mucous lesions. Carcinoma of the cervix is a major cause of death in women worldwide, and HPV infection a major risk factor for development of cervical carcinoma. During the malignant process, cell migration is a fundamental characteristic of tumor invasion, and the matrix metalloproteinases (MMPs) are responsible for the cleavage of extracellular matrix proteins. This project aims to investigate the expression of MMP-9 in different degrees of injury in the smear. We collected two cervical smears for cytological diagnosis and immunocytochemistry. Data collection was conducted in 630 women of the Sant´ana Women\ s Penitentiary, during the period August 2009 to August 2010. The slides were submitted to immunocytochemistry to detect the expression of MMP-9 and noticed an increase in protein expression in parallel with the increased lesions grade, which corroborates the histology of the literature and could be a method prognostic aid in vaginal smears.

ASSUNTO(S)

carcinoma cervical cervical carcinoma citologia cytology hpv hpv immunocytochemistry imunocitoquímica mmp mmp papillomavirus papilomavirus

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