Analgesia preemptiva do cetoprofeno e do parecoxibe em cirurgia para remoção de terceiros molares inclusos / Preemptive analgesia of the ketoprofen and parecoxib in the surgery to removal of impacted third molar teeth

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

This is a prospective, double-blind randomized, cross over experiment, to evaluate the effect of the preemptive analgesia of ketoprofen and parecoxib. Sixity patients who had gone though surgery for removal of the impacted mandibular bilateral third molar teeth, having one side operated each time, were evaluated. The patients were separated in groups of 30, in the parecoxib group (P). On the first operation parecoxib or placebo were used 30 minutes before the surgery. Immediately after the operation, placebo or parecoxib were administred, so that the patient who had received parecoxib before the operation or after it. The opposite side was operated two weeks after the first surgery and the patients who received parecoxib before and placebo after operation received placebo before and parecoxib after operation and patients who received placebo before and parecoxib after received parecoxib before and placebo after, under the same method. In the group C (n= 30), the model was the same, using ketoprofen instead parecoxib. The patient could use dipyrone as rescue medication, in the event of postoperative pain. A questionnaire was provided to the patient after each surgery, containing a visual analogic scale, a descriptive pain scale and a table to inform the consum of rescue medication. The postoperative pain was evaluated by visual analogic scale, descriptive pain scale and rescue medicine consum. There was no statistically relevant difference as pain intensity with use of parecoxib or ketoprofen before or after the surgical procedure. Comparing ketoprofen analgesia against parecoxib analgesial, the results shown that the administration of parecoxib before the surgical procedure had a major efficacy than ketoprofen in pain control by the fourth hour post operatory (p=0,041), but was less efficient after 24 hours (p=0,003). When comparing the analgesic effect of both drugs after the operation, parecoxib was more effective than ketoprofen six and eight hours after the procedure (p=0,003 and 0,023, respectively).

ASSUNTO(S)

cetoprofeno/administração e dosagem cetoprofeno/uso terapêutico dor pós-operatória/fisiopatologia antiinflamatórios não esteróides/uso terapêutico estudo comparativo ketoprofen/therapeutic use medição da dor/métodos analgesia/métodos analgesia/methods comparative study ketoprofen/administration and dosage terceiro molar/cirurgia dor pós-operatória/terapia molar third/surgery pain postoperative/therapy pain postoperative/physiopathology anti-inflammatory agentts non-steroidal/therapeutic use pain measurement/methods

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