Alterações imunologicas em individuos expostos ao chumbo

AUTOR(ES)
DATA DE PUBLICAÇÃO

1992

RESUMO

In thís work some effects of lead on the immune response were investigated. Sixty lead-acid battery workers were studied, as well as fifty non-exposed control individuals. To monitor exposure we used blood lead levels(PbB) as a measure of internal dose and delta-aminolevulinic acid in uríne(ALA-U) as an indicator of effect Phagocytosis and killing of Candida albicans and Candida pseudotropicalís. By neutrophils and Candida pseudotropicalis by monocytes levels of immunoglobulins G, M and A; and lymphocyte proliferation responses to the Mitogen phytohemagglutinin(PHA) were measured. The results obtained demonstrated that the phagocytic function of neutrophils and monocytes in lead-exposed workers did not differ from that of the controls. On the other hand, lysis of C. albicans by neutrophils was significantly decreased even in those workers with PbB and ALA-U concentrations below the threshold level value. Conversely the lysis of C.pseudotropicalis by neutrophíls and monocytes was not altered. We also observed in the exposed group a significant increase in the levels of IgM and IgA. However, the levels of IgG presented no changes. Blast lymphocyte transformatíon had no significant alterations, as compared to controls. The relatively low level lead absorption effects manifested by immunossupression indícates that immune dysfunction is a sensitive indicator of lead exposure

ASSUNTO(S)

chumbo toxicologia farmacologia

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