Adição de complexo vitamínico em duas bioceramicas e seu efeito na regeneração óssea / BONE REGENERATION EFFECT AFTER THE ADDITION OF A VITAMIN COMPLEX IN TWO BIOCERAMICS

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

One of the goals of the Biomaterials research is the development of devices that help bone regenaration. Two synthetic ceramics has been widely used with that purpose: Hidroxyapatite (HAp) and Beta tricalcium phosphate (b-TCP). In many situations it is desirable that the resorption rate of these materials by the body matches the bone growth rate. In these cases, the use of a mixture between the two phases is beneficial. The material resorption and bone growth are complexes phisiological processes, influenced amongst other things by the inflammatory response of the surgical site. That being said, an exacerbated inflammatory response is potentially hazardous, since it may induce an increase of the oxidative stress due to the free radicals production. The free radicals attack causes, amongst other hazardous effects, the cell membrane degenaration which in turn may lead to cell necrosis and/or apoptosis within the surgical site. In this work, two ceramics were implanted in rats femora: b-TCP or the biphasic mixture of 60:40% in mass of HAp:b-TCP. The bone growth was assessed by both optical and fluorescence microscopy, using fluorescent bone markers. Moreover, it was also evaluated the effect of the presence of a vitamin complex, mediator of the inflammatory response. It was concluded that the pure b-TCP was more readily absorbed when compared with the mixture b-TCP-HAp, and there it was signs that the presence of the vitamin complex may have helped in a favorable way the bone neoformation.

ASSUNTO(S)

biocerâmicas fosfato de cálcio fosfalto de cálcio regeneração óssea regeneração óssea ensaio in-vivo. biocerâmicas ensaio in-vivo.

ACESSO AO ARTIGO

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