Adaptações bioquimicas em fumantes e em pacientes portadores de doença pulmonar obstrutiva cronica (DPOC)

AUTOR(ES)
DATA DE PUBLICAÇÃO

1999

RESUMO

Patients suffering from Chronic Obstructive Pulmonary Disease (COPD) are likely to be adapted to hypoxic situation, as they present lower levels of oxygen saturated hemoglobin compared to normal individuais. This disease, as well as smoking habit potentially induce an increase on free radical generation what causes some biochemical adaptations. In the present work we have analysed some biomarkers for oxidative stress as well as other biochemical parameters which could be used to characterize specific adaptations induced by COPD or smoking. The study group comprized 40 to 80 years old male voluntiers, divided in COPD patients, smoking and non smoking individuais. The evaluated blood biomarkers were: the enzymatic activities of catalase (CAT) and glutathione reductase (GR) for the antioxidant defense system and creatine kinase (CK) for muscle injury; the concentrations of carbonyl proteins (PC), total sulphydryl groups (SH), uric acid (AV) and thiubarbituric acid reactive substances (TBARs) as indicators of oxidative attack, as well as hemoglobin and lactate concentrations. Our results show that the parameters saturation of oxygen, lactate, hemoglobin, creatine kinase, catalase and total sulphydryl groups can be used to characterize specific alterations observed in the three distinct groups

ASSUNTO(S)

antioxidantes pulmões - doenças fumo

ACESSO AO ARTIGO

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