Activation of memory circuits during cue-elicited cocaine craving.
AUTOR(ES)
Grant, S
RESUMO
Evidence accumulated over more than 45 years has indicated that environmental stimuli can induce craving for drugs of abuse in individuals who have addictive disorders. However, the brain mechanisms that subserve such craving have not been elucidated. Here a positron emission tomographic study shows increased glucose metabolism in cortical and limbic regions implicated in several forms of memory when human volunteers who abuse cocaine are exposed to drug-related stimuli. Correlations of metabolic increases in the dorsolateral prefrontal cortex, medial temporal lobe (amygdala), and cerebellum with self-reports of craving suggest that a distributed neural network, which integrates emotional and cognitive aspects of memory, links environmental cues with cocaine craving.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=38179Documentos Relacionados
- Generalized craving, self-report of arousal, and cue reactivity after brief abstinence
- Estudo da influência dos ácidos graxos poli-insaturados na dependência e no craving pelo álcool.
- Cocaine self-administration alters the relative effectiveness of multiple memory systems during extinction
- Role of personality traits in cocaine craving throughout an outpatient psychosocial treatment program
- Adaptação transcultural para o idioma português do Cocaine Craving Questionnaire - Brief