A simulation of microbial competition in the human colonic ecosystem.
AUTOR(ES)
Coleman, M E
RESUMO
Many investigations of the interactions of microbial competitors in the gastrointestinal tract used continuous-flow anaerobic cultures. The simulation reported here was a deterministic 11-compartment model coded by using the C programming language and based on parameters from published in vitro studies and assumptions were data were unavailable. The resource compartments were glucose, lactose and sucrose, starch, sorbose, and serine. Six microbial competitors included indigenous nonpathogenic colonizers of the human gastrointestinal tract (Escherichia coli, Enterobacter aerogenes, Bacteroids ovatus, Fusobacterium varium, and Enterococcus faecalis) and the potential human enteropathogen Salmonella typhimurium. Flows of carbon from the resources to the microbes were modified by resource and space controls. Partitioning of resources to the competitors that could utilize them was calculated at each iteration on the basis of availability of all resources by feeding preference functions. Resources did not accumulate during iterations of the model. The results of the computer simulation of microbial competition model and for various modifications of the model. The results were based on few measured parameters but may be useful in the design of user-friendly software to aid researchers in defining and manipulating the microbial ecology of colonic ecosystems as relates to food-borne disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=168170Documentos Relacionados
- Mixed-effect models for predicting microbial interactions in the vaginal ecosystem.
- Contribution of protozoa to lysine synthesis in the in vitro rumen microbial ecosystem.
- Distribution of Pseudomonas aeruginosa in a riverine ecosystem.
- Late Holocene human-induced modifications to a central Polynesian island ecosystem.
- Kelthane degradation by genetically engineered Pseudomonas aeruginosa BS827 in a soil ecosystem.