A primate species with limited major histocompatibility complex class I polymorphism.

AUTOR(ES)

Watkins, D I

RESUMO

Extensive polymorphism at the major histo-compatibility complex (MHC) is thought to confer immune protection on populations. A New World primate, the cotton-top tamarin (Saguinus oedipus), has a high prevalence of ulcerative colitis and adenocarcinoma of the colon and dies after infection with several human viruses. Lymphocytes from all animals tested expressed on common MHC class I allelic product. Another MHC class I allelic product was expressed by 39 of 41 tested animals. Four other allelic products were also expressed on the lymphocytes of these animals at a frequency of greater than 50%. MHC class II gene products, however, were polymorphic. Restriction fragment length polymorphism analysis confirmed that there were a limited number of cotton-top tamarin MHC class I alleles, whereas the MHC class II gene loci were polymorphic. This sharing of MHC class I alleles is unprecedented in a higher primate species and may play a role in the susceptibility of this endangered species to pathogens.

Documentos Relacionados

• Polymorphism of exon 2-3 of bovine major histocompatibility complex class I BoLa-A gene
• Analysis of HLA class I genes with restriction endonuclease fragments: implications for polymorphism of the human major histocompatibility complex.
• Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin.
• Evidence for extensive polymorphism of class I genes in the rat major histocompatibility complex (RT1).
• Mice lacking major histocompatibility complex class I and class II molecules.