A novel spatial transcription pattern associated with the segmentation gene, giant, of Drosophila.

AUTOR(ES)

Mohler, J

RESUMO

The segmentation gene, giant, is located in 3A1 within a cloned chromosome region surrounding the zeste locus. Rearrangement breakpoints associated with giant mutations were localized on the genomic clone map, and nearby transcription units were identified. One transcription unit is active during early embryogenesis and its transcripts are spatially localized from blastoderm into extended germband stages, consistent with expected expression patterns predicted by the 'gap' phenotype of giant mutants. Germ line transformation experiments using a 10-kb DNA fragment containing this transcription unit gave complete rescue of the abdominal giant defect but only partial correction of the head defect. The effect of mutations in three other gap loci, Kr, kni and hb, were also analyzed.

Documentos Relacionados

• Regulation of the segmentation gene fushi tarazu has been functionally conserved in Drosophila.
• Expression and novel structure of a collagen gene in Drosophila.
• Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.
• Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern.
• The expression and role of a proneural gene, achaete, in the development of the larval nervous system of Drosophila.