A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

Vita-Marques, Aline Maria de, Lira, Simone P., Berlinck, Roberto G. S., Seleghim, Mirna H. R., Sponchiado, Sandra R. P., Tauk-Tornisielo, Sâmia M., Barata, Margarida, Pessoa, Claudia, Moraes, Manoel O. de, Cavalcanti, Bruno Coêlho, Nascimento, Gislene G. F., Souza, Ana O. de, Galetti, Fabio C. S., Silva, Célio L., Silva, Marcio, Pimenta, Eli F., Thiemann, Otavio, Passarini, Michel R. Z., Sette, Lara D.

A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

AUTOR(ES)

Vita-Marques, Aline Maria de, Lira, Simone P., Berlinck, Roberto G. S., Seleghim, Mirna H. R., Sponchiado, Sandra R. P., Tauk-Tornisielo, Sâmia M., Barata, Margarida, Pessoa, Claudia, Moraes, Manoel O. de, Cavalcanti, Bruno Coêlho, Nascimento, Gislene G. F., Souza, Ana O. de, Galetti, Fabio C. S., Silva, Célio L., Silva, Marcio, Pimenta, Eli F., Thiemann, Otavio, Passarini, Michel R. Z., Sette, Lara D.

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2008

RESUMO

Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.