A Dirofilaria immitis Polyprotein Up-Regulates Nitric Oxide Production

AUTOR(ES)

Tezuka, Hiroyuki

FONTE

American Society for Microbiology

RESUMO

We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40−/−, mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.

Documentos Relacionados

• Estrogen-related receptor α1 up-regulates endothelial nitric oxide synthase expression
• Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition
• Neuronal activity up-regulates astroglial gene expression.
• Mycoplasma arthritidis mitogen up-regulates human NK cell activity.
• Nicotine Activates and Up-Regulates Nicotinic Acetylcholine Receptors in Bronchial Epithelial Cells