Antiretroviral Adverse Effects
Mostrando 13-24 de 28 artigos, teses e dissertações.
-
13. Rosiglitazona, agonista do PPAR-y "Peroxisome Proliferator-Activated Receptor-y" reverte a nefrotoxicidade induzida pelo tenofovir-DF / The peroxisome proliferator-activated receptor-y agonist rosiglitazone reverses tenofovir-induced nephrotoxicity
Objective: To characterize the mechanisms of tenofovir disoproxil fumarate (TDF)- induced nephrotoxicity and the protective effects of rosiglitazone (RSG), a peroxisome proliferator-activated receptor-y agonist. Methods: Rats were treated for 30 days with one of two TDF doses (50 or 300 mg/kg of food), to which RSG (92 mg/kg of food) was added for the last 1
Publicado em: 2008
-
14. Efeito do tratamento clínico sobre os índices de risco cardiovascular em indivíduos infectados pelo HIV / Effect of clinical treatment on cardiovascular score risk indexes in patients with HIV infection
Although HAART therapy has reduced AIDS morbid-mortality, it is associated to metabolic disturbances and increased cardiac risk profile. It is well established in clinical cardiology that cardiac risk scores can predict cardiovascular complications with great accuracy and are useful to guide interventions toward risk reduction. We designed this study to anal
Publicado em: 2008
-
15. Antiretroviral agents and acid-base balance at delivery of the neonate
Limited evidence is available regarding antiretroviral (ARV) safety for uninfected infants exposed to these drugs in utero. Our objective was to determine if ARV administered to pregnant women is associated with decreasing umbilical arterial pH and base excess in uninfected infants. A prospective study was conducted on 57 neonates divided into three groups:
Brazilian Journal of Medical and Biological Research. Publicado em: 11/06/2007
-
16. Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infants
This study assessed the effect of antiretroviral drugs administered to pregnant women on amylase and liver enzymes of the neonate. A prospective study was conducted on 52 neonates divided into three groups: infants born to HIV-infected mothers taking zidovudine (ZDV group, n = 18), infants born to mothers taking zidovudine + lamivudine + nelfinavir (TT group
Brazilian Journal of Infectious Diseases. Publicado em: 2007-06
-
17. Avaliação da duração e impacto do primeiro esquema anti-retroviral altamente potente em pacientes portadores da Síndrome da Imunodeficiência Adquirida (SIDA) em acompanhamento no Setor de Imunodeficiências do Serviço de Doenças Infecciosas e Parasitárias/ Hospital das Clínicas (DIP/HC) do Centro de Treinamento e Referência em Doenças Infecciosas e Parasitárias Orestes Diniz (CTR-DIP/UFMG-PBH) em Belo Horizonte, Minas Gerais.
The highly active antiretroviral therapy (HAART) improves substantially the prognosis of HIV infected patients. Finding a better regimen for the first antiretroviral treatment is one of the strategies used to improve time and quality of life of people living with HIV/AIDS. A total of 891 HIV infected patients assisted at the CTR-DIP Orestes Diniz and treated
Publicado em: 2007
-
18. Alterações no metabolismo lipídico e glicídico de crianças portadoras de HIV/aids atendidas na Unidade Mista de Saúde da Regional Sul (Hospital Dia) no Distrito Federal, Brasil
The implementation of Highly Active Antiretroviral Therapy (HAART) in combination regimens has profoundly decreased mortality and disease progression in children infected with the human immunodeficiency virus. These, however, are more vulnerable for the adverse effects of the therapy because they must be treated for a long time. The metabolic effects of the
Publicado em: 2006
-
19. Characteristics of HIV antiretroviral regimen and treatment adherence
The relationship between characteristics of HIV antiretroviral regimens and treatment adherence was studied in adolescent and adult patients who underwent antiretroviral therapy from January 1998 to September 2000, at the Service for Specialized Assistance in Pelotas. The patients were interviewed on two occasions, and the use of antiretrovirals during the p
Brazilian Journal of Infectious Diseases. Publicado em: 2003-06
-
20. Hyperlipidaemia - a risk factor for femoral head osteonecrosis (Legg-Calvè-Perthes-Like disease) in children with AIDS: case report
Although treatment of children infected with HIV with protease inhibitors has improved the survival of these patients, various adverse side effects have been reported, including metabolic abnormalities, such as hyperlipidaemia. We describe a case of hip osteonecrosis in an adolescent with AIDS who was being treated with protease inhibitors. There is a possib
Brazilian Journal of Infectious Diseases. Publicado em: 2002-06
-
21. Adverse effects of antiretroviral therapy for HIV infection
LONG-TERM REMISSION OF HIV-1 DISEASE CAN BE READILY ACHIEVED by combinations of antiretroviral agents. The suppression of plasma viral loads to less than the limit of quantification of the most sensitive commercially available assays (i.e., less than 50 copies/mL) and the coincident improvement in CD4 T cell counts is associated with resolution of establishe
-
22. Symptomatic hyperlactatemia in an HIV-positive patient: a case report and discussion
PROLONGED EXPOSURE TO HIGHLY ACTIVE antiretroviral therapy may be associated with adverse effects related to mitochondrial toxicity, such as hyperlactatemia. We describe a case of symptomatic hyperlactatemia in an HIV-positive patient to illustrate the subtle clinical symptoms and abnormal laboratory test results associated with this condition. We also revie
-
23. Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy
The introduction of highly active antiretroviral therapy (HAART) has significantly decreased morbidity and mortality among patients infected with HIV-1. However, HIV-1 can acquire resistance against all currently available antiretroviral drugs targeting viral reverse transcriptase, protease, and gp41. Moreover, in a growing number of patients, the developmen
American Society for Clinical Investigation.
-
24. Pharmacological Basis for Concentration-Controlled Therapy with Zidovudine, Lamivudine, and Indinavir
Conventional antiretroviral therapy involves administration of standard fixed doses to adults and adolescents. This approach ignores interindividual variability in pharmacokinetics and results in substantial differences in systemic concentrations among patients. Thus, variability in systemic concentrations contributes to variability in response to therapy. T
American Society for Microbiology.