Antigenotoxicity
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Genotoxicity, anti-melanoma and antioxidant activities of Hymenaea courbaril L. seed extract
Abstract: Hymenaea courbaril has been used to treat different diseases, although its properties are yet to be scientifically validated. The objective of this study was to determine the cytotoxicity, genotoxicity, antigenotoxicity and antioxidant potentials of hydroethanolic extract from H. courbaril seeds. Therefore, for the cytotoxicity test an anti-melanom
An. Acad. Bras. Ciênc.. Publicado em: 02/12/2019
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2. Protective effects of bark ethanolic extract from Spondias dulcis Forst F. against DNA damage induced by benzo[a]pyrene and cyclophosphamide
Abstract This study evaluated the genotoxicity, mutagenicity, antigenotoxicity, and antimutagenicity effects on biochemical parameters of oxidative stress of the Spondias dulcis bark ethanolic extract on mice. The extract was evaluated in the doses of 500, 1000, and 1500 mg/kg bw via gavage. To evaluate the protective effects of the extract, benzo[a]pyrene (
Genet. Mol. Biol.. Publicado em: 14/11/2019
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3. In vivo assessment of cyto/genotoxic, antigenotoxic and antifungal potential of Costus spiralis (Jacq.) Roscoe leaves and stems
ABSTRACT Costus spiralis is a Brazilian native plant used in popular medicine, but the safety of this therapeutic use needs investigation. So, the aim of this study was to evaluate the cytogenotoxic and antigenotoxic effects of C. spiralis leaves or stems aqueous extracts on Allium cepa root cells. Moreover, a phytochemical screening and an antioxidant and a
An. Acad. Bras. Ciênc.. Publicado em: 23/04/2018
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4. Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow
ABSTRACT The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/kg bw with 4 mg/kg bw MMC or 50 mg/kg b
An. Acad. Bras. Ciênc.. Publicado em: 29/06/2017
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5. Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
Abstract Brazilian green propolis is a resinous substance prepared by bees from parts of the plant Baccharis dracunculifolia. As it possess several biological properties, this work assessed the cytotoxic/anticytotoxic, genotoxic/antigenotoxic and mutagenic/antimutagenic potential of ethanolic extracts of Brazilian green propolis (EEGP) and of B. dracunculifo
Genet. Mol. Biol.. Publicado em: 24/05/2016
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6. In vivo evaluation of the antimutagenic and antigenotoxic effects of β-glucan extracted from Saccharomyces cerevisiae in acute treatment with multiple doses
Ample evidence suggests that cancer is triggered by mutagenic damage and diets or supplements capable of reducing such incidences can be related to the prevention of neoplasy development or to an improvement in life quality of patients who undergo chemotherapy. This research aimed to evaluate the antimutagenic and antigenotoxic activity of β-glucan. We set
Genet. Mol. Biol.. Publicado em: 19/07/2013
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7. Antigenotoxic activity of diet compounds and their influence in the expression of genes involved in response to oxidative stress / Atividade antigenotóxica de compostos da dieta e sua influência na expressão de genes de resposta ao estresse oxidativo
Os pigmentos naturais, além de fornecerem cor e beleza aos diferentes organismos, desempenham importantes funções e ações biológicas, como as funções vitais de fotossíntese, respiração celular e a ação antioxidante. Assim, o presente estudo investigou os potenciais citotóxicos, genotóxicos e protetores dos pigmentos naturais clorofila b (CLb)
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2012
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8. The influence of organic solvents on estimates of genotoxicity and antigenotoxicity in the SOS chromotest
In this work, the toxicity and genotoxicity of organic solvents (acetone, carbon tetrachloride, dichloromethane, dimethylsulfoxide, ethanol, ether and methanol) were studied using the SOS chromotest. The influence of these solvents on the direct genotoxicity induced by the mutagens mitomycin C (MMC) and 4-nitroquinoline-1-oxide (4-NQO) were also investigated
Genetics and Molecular Biology. Publicado em: 2012
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9. The antigenotoxic activity of latex from Himatanthus articulatus
Himatanthus articulatus (Vahl) Woodson (Apocynaceae) is a native plant to the Amazon popularly used to treat ulcers, tumors, inflammations, cancer, syphilis and malaria. The aim of the present study was to investigate the in vivo genotoxic/antigenotoxic and mutagenic potential of this plant, using the comet and the micronucleus assays in mice. Female and mal
Revista Brasileira de Farmacognosia. Publicado em: 29/11/2011
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10. Chemical composition and antigenotoxic properties of Lippia alba essential oils
The present work evaluated the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity. EO constituents were determined by Gas Chromatography/Mass Spectrometric (GC-MS) analysis. The major compounds encountered being citral (33% geranial and 25% neral), geraniol (7%) and trans-β-
Genetics and Molecular Biology. Publicado em: 29/07/2011
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11. Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice
Melissa officinalis (L.) (Lamiaceae), a plant known as the lemon balm, is native to the east Mediterranean region and west Asia. Also found in tropical countries, such as Brazil, where it is popularly known as "erva-cidreira" or "melissa", it is widely used in aqueous- or alcoholic-extract form in the treatment of various disorders. The aim was to investigat
Genetics and Molecular Biology. Publicado em: 2011
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12. Investigação das atividades mutagênica, antimutagênica e antioxidante de extratos etanólicos de Aiouea trinervis, Nectandra cissiflora, Ocotea minarum (Lauraceae) e dos alcalóides triptofol, ocoteína e dicentrina
The Brazilian cerrado (tropical American savanna) is a semi-arid region in which plants are submitted to metabolic stress that triggers defense mechanisms when confronted with unfavorable environmental conditions. The Lauraceae is an economically important family with 52 genera and approximately 2500-2750 species consisting mostly of trees or tree-like shrub
Publicado em: 2008