Anticoagulant Drugs
Mostrando 1-12 de 21 artigos, teses e dissertações.
-
1. Drug Interactions and Adverse Events in a Cohort of Warfarin Users Attending Public Health Clinics
Abstract Background: Warfarin is an oral anticoagulant involved in important interactions with foods and other drugs. Objectives: To evaluate the occurrence of adverse events reported by warfarin users and their relationship with drug interactions. Methods: This was an open cohort, prospective study conducted in an 18-month period with warfarin users atte
Int. J. Cardiovasc. Sci.. Publicado em: 17/12/2018
-
2. Thrombin generation assays for global evaluation of the hemostatic system: perspectives and limitations
Abstract The existing techniques to evaluate hemostasis in clinical laboratories are not sensitive enough to detect hypercoagulable and mild hypocoagulable states. Under different experimental conditions, the thrombin generation test may meet these requirements. This technique evaluates the overall balance between procoagulant and anticoagulant forces and ha
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-09
-
3. Current status of rodenticide intoxication in Brazil: a preliminary survey from 2009 to 2011
The chemical control of rodents with anticoagulant products, especially derivatives of the coumarin chemical group, is legally authorised in Brazil. These products provide effective control and are safe for humans. However, the use of illegal 'rodenticides' has increased in many Brazilian cities recently, accompanied by increased numbers of suicides, homicid
Braz. arch. biol. technol.. Publicado em: 2014-10
-
4. Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats
PURPOSE: To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats.METHODS:Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 mg/kg/day 400UI/Kg/day. The rats were divided into f
Acta Cir. Bras.. Publicado em: 2014-07
-
5. Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos
Cardiovascular diseases are responsible for the largest number of deaths among humans worldwide, including heart attacks, strokes, and thrombosis. The treatment of thrombosis is generally through the administration of anticoagulant and/or antiplatelet drugs, which have some clinical limitations. Plants synthesize a wide variety of bioactive metabolites in re
Química Nova. Publicado em: 2010
-
6. Preparação e caracterização de nanoparticulas com heparina e sua avaliação em modelo animal de trombose venosa / Preparation and characterization of heparin-loaded nanoparticles and its evaluation in animal model of venous thrombosis
Heparin is an anticoagulant widely used in the treatment and prophylaxis of deep vein thrombosis (DVT). Some limitations of its use is the cost and route of administration, intravenous or subcutaneous, sometimes in repeated doses in 24 hours. Thus, the development of a product that can be administered subcutaneously in a smaller number of applications or ora
Publicado em: 2010
-
7. Caracterização parcial e atividades farmacológicas do extrato rico em polissacarídeos sulfatados da angiosperma marinha Halodule wrightii
Sulfated polysaccharides (PS) are biomolecules with a great biotechnological potential. There are few data about PS from high plants. In addition, pharmacological activities of PS from plants have not been carrying out. The aim of this work was extract PS from the angiosperm Halodule wrightii and study their anticoagulant and antioxidant activities. Histolog
Publicado em: 2008
-
8. Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment.
OBJECTIVE--To determine whether the finding of antiphospholipid antibodies in patients with venous thromboembolic episodes should influence the duration of treatment with anticoagulant drugs by mouth. METHODS--A retrospective study was carried out in 19 patients with antiphospholipid antibodies and a history of venous thromboembolic episodes. The median foll
-
9. STUDIES ON THE COUMARIN ANTICOAGULANT DRUGS: THE PHARMACODYNAMICS OF WARFARIN IN MAN*
-
10. International and national standardization of control of anticoagulant therapy in patients receiving coumarin and indanedione drugs using calibrated thromboplastin preparations.
-
11. Long-term anticoagulation. Indications and management.
Each year half a million persons in the United States receive long-term anticoagulant therapy to prevent venous and arterial thromboembolism. Unfortunately, the relative benefits and risks of anticoagulant therapy have not been adequately quantified for many thromboembolic disorders, and the decisions as to whether, for how long, and how intensely to adminis
-
12. Crystal structure of an anticoagulant protein in complex with the Gla domain of factor X
The γ-carboxyglutamic acid (Gla) domain of blood coagulation factors is responsible for Ca2+-dependent phospholipid membrane binding. Factor X-binding protein (X-bp), an anticoagulant protein from snake venom, specifically binds to the Gla domain of factor X. The crystal structure of X-bp in complex with the Gla domain peptide of factor X at 2.3-Å resolut
The National Academy of Sciences.