Afro Brazilian Populations
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Human leukocyte antigen allele linkage disequilibrium and haplotype structure in volunteer bone marrow donors of Paraná State
Abstract Background Bone marrow transplantation has been used in the treatment of various diseases, especially hematologic diseases. The success of this treatment, among other factors, requires human leukocyte antigens (HLA) compatibility between patient and donor. Knowing the human leukocyte antigens allele group and haplotype frequencies as well as the li
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-09
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2. Inherited hemoglobin disorders in an Afro-Amazonian community: Saracura
The most common hemoglobinopathies, viz, hemoglobins S and C, and α-and β-thalassemias, were investigated through the molecular screening of 116 subjects from the community of Saracura, comprising fugitive African slaves from farms of the municipality of Santarém, in the west of Pará State, Brazilian Amazon. The observed frequency of the HBB*S gene (0.9%
Genetics and Molecular Biology. Publicado em: 05/07/2012
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3. HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow donors from the north of Parana state
BACKGROUND: Knowledge of allele and haplotype frequencies of the human leukocyte antigen (HLA) system is important in the search for unrelated bone marrow donors. The Brazilian population is very heterogeneous and the HLA system is highly informative of populations because of the high level of polymorphisms. AIM: The aim of this study was to characterize the
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2012
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4. Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
Antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX1) reduce the oxidation rates in the organism. Gluthatione S-transferases (GSTs) play a vital role in phase 2 of biotransformation of many substances. Variation in the expression of these enzymes suggests individual differences for the degree of antioxidant protect
Genetics and Molecular Biology. Publicado em: 26/11/2010
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5. (TTTA)n polymorphism of CYP19 (aromatase gene) in Euro-and Afro-Brazilians
We investigated the polymorphic tetranucleotide repeat (TTTA)n located in the fourth intron of the CYP19 gene in two Brazilian populations. The frequencies of the five common alleles (A) in Euro- and Afro-Brazilians were, respectively: seven repeats (A5), 0.586 and 0.80; eight repeats (A4), 0.092 and 0.06; nine repeats (A3), 0.014 and 0.01; eleven repeats (A
Publicado em: 2010
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6. CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group
Gene polymorphisms involved in the metabolism of drugs and chemical carcinogens seem to be responsible for differences in the susceptibility of individuals to cancer, but genetic population studies are needed to characterize these polymorphisms in different ethnic populations. We investigated polymorphisms of the cytochrome P450 (CYP) gene CYP1A1 and the glu
Publicado em: 2010
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7. Mitochondrial DNA mapping of social-biological interactions in Brazilian Amazonian African-descendant populations
The formation of the Brazilian Amazonian population has historically involved three main ethnic groups, Amerindian, African and European. This has resulted in genetic investigations having been carried out using classical polymorphisms and molecular markers. To better understand the genetic variability and the micro-evolutionary processes acting in human gro
Publicado em: 2010
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8. Determinação dos níveis séricos de vitamina D em uma amostra de indivíduos saudáveis da população brasileira / Determination of the vitamin D levels in healthful individuals of the Brazilian population
Vitamin D insufficiency (25(OH)D <30 ng/mL) is frequently under-diagnosed, mainly in countries where solar radiation is abundant. The reduction of this hormone is related to the development of bone metabolic alterations, secondary hyperparathyroidism (SHPT) and greater risk of chronic illnesses. OBJECTIVE: To evaluate the status of vitamin D and the relation
Publicado em: 2010
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9. Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants
Individual variability in xenobiotic metabolism has been associated with susceptibility to developing complex diseases. Genes involved in xenobiotic metabolism have been evaluated in association studies; the difficulty of obtaining accurate gene frequencies in mixed populations makes interpretation of the results difficult. We sought to estimate population p
Genetics and Molecular Biology. Publicado em: 23/10/2009
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10. Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp*1 and Hp*2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequen
Genetics and Molecular Biology. Publicado em: 26/06/2009
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11. Analysis of the CCR5 gene coding region diversity in five South American populations reveals two new non-synonymous alleles in Amerindians and high CCR5*D32 frequency in Euro-Brazilians
The CC chemokine receptor 5 (CCR5) molecule is an important co-receptor for HIV. The effect of the CCR5*D32 allele in susceptibility to HIV infection and AIDS disease is well known. Other alleles than CCR5*D32 have not been analysed before, neither in Amerindians nor in the majority of the populations all over the world. We investigated the distribution of t
Genetics and Molecular Biology. Publicado em: 16/01/2009
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12. Artrite reumatoide em Afro-brasileiros : "O papel do HLA" / Rheumatoid arthritis in Afro-brazilians : "The role of HLA"
The association of histocompatibility antigens with Rheumatoid Arthritis (RA) comes being demonstrated in innumerable studies. However, the evaluation in afrodescendents populations still little was studied. The aim of this study has been to determine the frequency of HLA-DRB1 alleles, and the contributions of the polymorphism of these alleles in the suscept
Publicado em: 2009