Acute And Sub Chronic Toxicity
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Chemical characterization and toxicological assessment of hydroethanolic extract of Mandevilla velame xylopodium
Abstract The present study was aimed to characterize the chemical profile and evaluate the cytotoxicity and sub-chronic toxicity of the hydroethanolic extract of the xylopodium Mandevilla velame (A.St.-Hil.) Pichon, Apocynaceae. Chemical profile was analyzed by high performance liquid chromatography. Cytotoxic potential of hydroethanolic extract of the xylop
Rev. bras. farmacogn.. Publicado em: 09/12/2019
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2. Sub-chronic toxicity evaluation of Dryopteris filix-mas (L.) schott, leaf extract in albino rats
This study evaluated the acute and sub-chronic toxicities of ethanol leaf extract of Dryopteris filix-mas. Acute toxicity and phytochemical tests on ethanol leaf extract were determined. In sub-chronic toxicity test, animals were treated with 62.5, 125, 250 and 500 mg/kg of extract every day for 90 days. Blood samples were collected via retro-orbital punctur
Braz. J. Pharm. Sci.. Publicado em: 03/10/2019
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3. Inhibitory effect of Lonchocarpus araripensis lectin in rat acute models of inflammation
Abstract: Dalbergieae tribe lectins, possessing binding affinity for galactose and mannose, present inflammatory and nociceptive effects, while those for N-acetylglucosamine are anti-inflammatory. Since the anti-inflammatory effect of the seed lectin of L. araripensis (LAL) had been already demonstrated in mice, this effect was presently evaluated in rat mod
An. Acad. Bras. Ciênc.. Publicado em: 19/06/2019
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4. A subchronic toxicity study of ethanol root extract of baked Aconitum flavum in rats
ABSTRACT The genus Aconitum has strong toxicity, but the acute toxicity of baked Aconitum flavum Hand.-Mazz., Ranunculaceae, was reduced significantly on the premise of keeping anti-inflammatory and anti-nociceptive activities. However, the risk associated with long-term use is unknown. In a sub-chronic toxicity study, rats were orally administered A. flavum
Rev. bras. farmacogn.. Publicado em: 2016-08
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5. Acute and subchronic toxicological evaluation of Echinophora platyloba DC (Apiaceae) total extract in Wistar rats
OBJECTIVE: Echinophora platyloba DC is a widely used herbal medicine and food seasoning in Iran. It is claimed to exert antimicrobial, antifungal, and antispasmodic effects. Despite the prevalent use of this plant as a food and medicine, there are no reports on its possible toxic effects. To evaluate the safety of E. platyloba, we tested its acute and sub-ch
Clinics. Publicado em: 2012
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6. Acute toxicological effects of extracts of Melia azedarach (Meliaceae) in rats (Rattus norvegicus), mice (Mus musculus) and Artemia salina / Efeitos toxicológicos agudos de extratos de Melia azedarach (MELIACEAE) em ratos (Rattus novergicus), camundongos (Mus musculus) e Artemia salina
The revival of research involving botanical insecticides owes itself to the need to make available new products devoid of environmental degradation, with lesser residual affects and development of resistant insects to synthetic products. Phytochemicals from the family Meliaceae have been considered preeminent pesticides. Among the Maliaceae, one of the plant
Publicado em: 2010
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7. STUDY OF SUBLETHAL AND LETHAL EFFECTS (REPRODUCTION AND TERATOGENISIS) OF THE PHARMACEUTICAL COMPOUND TRICLOSAN TO Daphnia similis, Ceriodaphnia dubia, and Ceriodaphnia silvestrii (CLADOCERA, CRUSTACEA) / Estudos dos efeitos letais e subletais (reprodução e teratogênese) do farmáco triclosan para Daphnia similis, Ceriodaphnia dubia, Ceriodaphnia silvestrii (Cladocera, crustacea)
Until recently, the knowledge of contamination on aquatic ecosystems was restricted to metals and pesticides, with little emphasis on pharmaceuticals. Despite being found in concentrations of nanograms to micrograms per litre, these compounds can cause lethal and development defects on living organisms. Ecotoxicological studies have been performed to identif
Publicado em: 2008
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8. AvaliaÃÃo toxicolÃgica prÃ-clÃnica do Ãleo de Carapa guianensis Aublet.
Carapa guianensis (Meliaceae), a typical tree from amazon region, is popularly known as Andiroba. Its seed oil is used as anti-inflammatory, analgesic and insect repellent. Although C. guianensis is largely used by people, there are no studies concerning its toxicity. In this way, the aim of this work was to evaluate the safety of the C. guianensis seed oil
Publicado em: 2006
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9. Avaliação toxicologica e farmacologica do complemento nutricional "TK3" / "TK3" : association between L-tryptophan and thymine toxicological and pharmacological studies
The nutritional supplement ?TK3? was originally studied by a German biochemist, Mr. Friedrich Lavitcshka, who first associated L-tryptophan and thymine, in a liquid formula, in 1969. His early studies using experimental tar-induced skin cancer models were not published even though they seemed to confirm the benefits reported by informal use of such associati
Publicado em: 2006
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10. Atividade cicatrizante e avaliaÃÃo toxicolÃgica prÃ-clÃnica do fitoterÃpico sanativo
O Sanativo (SAN) à um produto fitoterÃpico composto de uso tradicional na regiÃo Nordeste do Brasil. Este medicamento sob a forma de extrato fluido à indicado no tratamento de feridas, queimaduras, inflamaÃÃes de garganta e de tecidos epiteliais lesionados. Sua fÃrmula à constituÃda por 20% de angico (Piptadenia colubrina, Benth), que possui aÃÃ
Publicado em: 2006
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11. AVALIAÇÃO DO POTENCIAL ANTIFÚNGICO DE ÓLEOS ESSENCIAIS DE PLANTAS DO NORDESTE BRASILEIRO FRENTE A DIFERENTES CEPAS DE MICROSPORUM CANIS, CANDIDA SPP E MALASSEZIA PACHYDERMATIS
Mycoses are serious public health concern specially in subtropical and tropical regions with dermatophytes and yeast infections being the most common pathogens. This work was undertaken in order to test whether essential oils extracted from the leaves of Croton species (Croton nepetaefolius, Croton argyrophylloides and Croton zehntneri) or from Lippia sidoid
Publicado em: 2005
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12. Atividade antiinflamatória, toxicidade e fitoquímica do óleo-resina de copaíba, proveniente de diferentes espécies, e de suas respectivas frações (OU) Atividade antiinflamatória, toxicidade e aspectos químicos do óleo-resina de Copaíba, proveniente de diferentes espécies, e de suas frações / Anti-inflamatory activity, toxicity and chemical composition of Copaifera oils, from different species, and theirs fractions
Species of the genus Copaifera (Leguminosae) are native of tropical regions in Latin America and Africa. In Brazil, its oil-resin is widely utilized in popular medicine as anti-inflammatory, antiseptic and cicatrizing medicine. In the present work, we initially evaluated the acute anti-inflammatory activity of the following samples: commercial, Copaifera ret
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/06/2001