Acetylcholine Agonists
Mostrando 1-12 de 187 artigos, teses e dissertações.
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1. Consequências dos tratamentos realizados com celecoxibe, -tocoferol ou losartan sobre a reatividade em carótidas de ratos submetidos à lesão com cateter balão / Consequences of the treatments performed with celecoxib, -tocopherol or losartan on the carotid of reactivity in rats subjected to injury with balloon catheter.
The injury by balloon catheter is a procedure commonly used to study the mechanisms of restenosis. The mechanical stress produced by the passage of the balloon promotes changes both in the injured artery in the contralateral artery. There was an increased density of neurons containing neuropeptides such as substance P (SP) and the Gene Related Peptide of Cal
Publicado em: 2009
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2. Structural studies of acetylcholine agonists by NMR spectroscopy and theoretical calculations / Estudos estruturais de agonistas de acetilcolina pela espectroscopia de RMN e calculos teoricos
This work describes the conformational analysis of muscarine agonists of acetylcholine (ACh+): carbachol, metacholine and pilocarpine. It was performed from the analysis of 3JHH coupling constants and from ab initio theoretical calculations. Their conformational behavior is discussed taking into account the most important dihedral angles. Both the results fr
Publicado em: 2008
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3. Analise histologica do aparato venenifero e caracterização farmaco-bioquimica da peçonha de Vitalius dubius (Araneae, Theraphosidae) / Histological analysis of the venom apparatus and biochemical and pharmacological characterization of venom from Vitalius dubius (Araneae, Theraphosidae)
Vitalius dubius is a medium-sized, non-aggressive tarantula found in southeastern Brazil. In this work, we examined the histological organization of the venom apparatus of V. dubius and investigated some biochemical and pharmacological properties of this spider´s venom. The venom apparatus consisted of two chelicerae fitted with large fangs for prey immobil
Publicado em: 2008
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4. Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
Anatoxin-a and its analogues are azabicyclic alkaloids that represent one of the most powerful nicotinic agonists known for the nicotinic acetylcholine receptor (nAChR). Because of this potent mechanism of action, anatoxin-a and its derivatives represent a target for the discovery of novel drugs. Their syntheses are useful for environmental monitoring and al
Química Nova. Publicado em: 2006-12
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5. Ação de drogas agonistas e antagonistas dos sistemas colinérgico e dopaminégico: estudo comportamental e neuroquímico em corpo estriado de rato. / The action of the agonists and antagonists drugs of cholinergic and dopaminergic systems: behavioral and neurochemical study in striatum of rats
In the study, the interaction between the dopaminergic and cholinergic systems through the study of behavioral (open field and catalepsy) and neurochemical (density of dopaminergic receptor (D1 and D2-like) and muscarinic (M1+M2-like)) effect in striatum rat was evaluated. The following drugs were used: mazindol (indirect dopaminergic agonist), apomorphine (
Publicado em: 2005
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6. Effects of Levetiracetam on pilocarpine-induced seizures in mice / Efeitos do levetiracetan no modelo de convulsões induzidas por pilorcarpina em camundongos
Levetiracetam (LEV) is a new antiepileptic drug effective as adjunctive therapy for partial seizures and in experimental models of seizures, including pilocarpine-induced seizures in rodents. Objectifying to clarify if anticonvulsant activity of LEV occurs near cholinergic muscarinic alterations, adult male mice received LEV injections before muscarinic agon
Publicado em: 2005
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7. Ionic radiocontrast inhibits endothelium-dependent vasodilation of the canine renal artery in vitro: possible mechanism of renal failure following contrast medium infusion
To determine if radiocontrast impairs vascular relaxation of the renal artery, segments (4-5 mm in length) of canine renal artery were suspended in vitro in organ chambers to measure isometric force (95% O2/5% CO2, at 37ºC). Arterial segments with and without endothelium were placed at the optimal point of their length-tension relation and incubated with 10
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-02
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8. Caracterização farmacologica do relaxamento da musculatura lisa do corpo cavernoso humano isolado induzido por cininas
Objective: To caracterize the kinin receptor subtype involved in the relaxation of human isolated corpus cavernosum (HCC) induced by bradykinin (BK). Lysbradykinin (Lys-BK), Met-Lys-bradykinin (Met-Lys-BK) and des-Arg9-bradykinin (des-Arg9-BK), and to investigate whether the kinin-induced relaxation of HCC results from the stimulation of nonadrenergic, nonch
Publicado em: 2002
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9. Caracterização farmacologica do relaxamento de corpo cavernoso de coelho induzido pelo veneno de Tityus serrulatus
Títyus serrufatus ís the most dangerous scorpíon of the subfamily Tityinae in Brazíl because of the high toxicity of its venom and its widespread distribution in populous urban centers of southeastern region of the country. The most important clinical manifestations of the human envenomation by Títyus serrulatus are intense local pain and an immediate l
Publicado em: 1997
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10. Estudo farmacolÃgico da ternatina, um flavonÃide isolado de Egletes viscosa, LESS / FarmacolÃgico study of the ternatina, an isolated flavonÃide of Egletes viscose, LESS
Ternatin (5, 4â-dihydroxy-3, 7, 8, 3â-tetrametoxy-flavone), a flavonoid which was extracted and purified from Egletes viscosa, Less. (Compositae), was screened for various pharmacological effects in experimental animals. The compound (15 and 30 mg/kg, i.p.) demonstrated a dose-related significant anti- inflammatory effect in the carrageenan-induced rat hin
Publicado em: 1991
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11. Histrionicotoxin enhances agonist-induced desensitization of acetylcholine receptor.
Dihydroisohistrionicotoxin inhibits acetylcholine receptor-dependent 22Na+ uptake of cultured chick muscle cells with a KI of 0.2 micrometer. The inhibition is noncompetitive with respect to agonists. The toxin enhances desensitization of the receptor by agonists which is accompanied by a 10-fold increase in receptor affinity for agonists. Dihydroisohistrion
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12. Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor
The pentameric acetylcholine-binding protein (AChBP) is a soluble surrogate of the ligand binding domain of nicotinic acetylcholine receptors. Agonists bind within a nest of aromatic side chains contributed by loops C and F on opposing faces of each subunit interface. Crystal structures of Aplysia AChBP bound with the agonist anabaseine, two partial agonists
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