Abin
Mostrando 13-14 de 14 artigos, teses e dissertações.
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13. Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
At least eight types of ubiquitin chain exist, and individual linkages affect distinct cellular processes. The only distinguishing feature of differently linked ubiquitin chains is their structure, as polymers of the same unit are chemically identical. Here, we have crystallized Lys 63-linked and linear ubiquitin dimers, revealing that both adopt equivalent
Nature Publishing Group.
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14. NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain
An important property of NEMO, the core element of the IKK complex involved in NF-κB activation, resides in its ability to specifically recognize poly-ubiquitin chains. A small domain called NOA/UBAN has been suggested to be responsible for this property. We recently demonstrated that the C-terminal Zinc Finger (ZF) of NEMO is also able to bind ubiquitin. W
Nature Publishing Group.