2 3 Dioxygenase Ido
Mostrando 1-12 de 38 artigos, teses e dissertações.
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1. Vascular endothelial growth factor-A enhances indoleamine 2,3-dioxygenase expression by dendritic cells and subsequently impacts lymphocyte proliferation
Dendritic cells (DCs) are antigen (Ag)-presenting cells that activate and stimulate effective immune responses by T cells, but can also act as negative regulators of these responses and thus play important roles in immune regulation. Pro-angiogenic vascular endothelial growth factor (VEGF) has been shown to cause defective DC differentiation and maturation.
Mem. Inst. Oswaldo Cruz. Publicado em: 09/10/2013
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2. Nível de expressão tumoral da indoleamine 2,3-dioxigenase (IDO) como marcador biológico e preditor de metástase em pacientes com tumor carcinoide típico broncopulmonar / Tumor Expression Level of Indoleamine 2,3 dioxygenase as Biological Marker and Metastasis Predictor in Patients with Typical Bronchopulmonary Carcinoid Tumors
Os tumores carcinoides típicos broncopulmonares (TCTB) são considerados neoplasias bem diferenciadas e as menos agressivas dentro do espectro dos tumores neuroendócrinos. Entretanto, metástases linfonodais e hematogênicas tem sido encontradas em número considerável de casos e não existem, até o momento, estudos relacionados aos mecanismos de escape
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/12/2011
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3. Metabolismo de triptofano na vigência de choque endotóxico induzido por LPS e hipertriptofanemia / Metabolism of tryptophan in the presence of LPS-induced endotoxic shock and hypertryptofanemia
Triptofano (TRP), um amino ácido essencial, é metabolizado por duas vias principais, a via das quinureninas e a via serotonérgica. Em ambas as vias há a possibilidade de formação de compostos ativos no sistema imune que se caracterizam pelas ações imunossupressoras e indutoras de tolerância. Na via serotonérgica há a formação de serotonina (5-HT
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2010
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4. Susceptibilidade diferencial de células trofoblásticas humanas (BeWo) e cervicais uterinas (HeLa) à infecção por Neospora caninum
Neospora caninum is an obligate intracellular parasite, closely related to Toxoplasma gondii, and considered a major cause of abortion and congenital neosporosis in cattle worldwide. As trophoblast cells act in mechanisms of innate immune defense at fetal-maternal interface, and no data are available about the interaction of this parasite with human trophobl
Publicado em: 2010
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5. IDO controls the fungal loads and cellular immunity in pulmonary paracoccidiodomycosis developed by susceptible and resistant mice to the fungus. / A IDO controla a carga fúngica e a imunidade celular de camundongos suscetíveis e resistentes à infecção pelo Paracoccidioides brasiliensis.
Indoleamine-2, 3-dioxygenase (IDO) and tryptophan catabolism are involved in the control of innate and adaptive immunity against pathogens. We investigated the role of IDO in the pulmonary paracoccidiodomycosis developed by susceptible (B10.A) and resistant (A/J) mice to the fungus. We verified that IDO plays a different effect in innate the immunity of B10.
Publicado em: 2009
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6. Degradation of tryptophan in bovine placenta in normal and cloned pregnancy: is this an evidence of indoleamine 2,3-dioxygenase activity? / Degradação de triptofano na placenta bovina em gestações normais e de clones: evidência da atividade da indoleamina 2,3-dioxigenase?
A tolerância materno-fetaI continua a ser um intrigante enigma imunológico. Algumas teorias têm sido propostas sobre o estabelecimento deste estado, tais como a produção de moléculas solúveis como HLA-G (na gestação humana) por células fetais que inibiriam a atividade de células do sistema imune inato. Além da secreção de hormônios; liberaçã
Publicado em: 2005
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7. Cytokines Induce Indoleamine 2,3-Dioxygenase Expression in Human Atheroma-Associated Cells: Implications for Persistent Chlamydophila pneumoniae Infection
This study shows that vascular smooth muscle cells express significantly higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (IDO) activity than endothelium or mononuclear cells. Since IDO activity is linked to persistent Chlamydophila pneumoniae infection, our results suggest that smooth muscle cells may be an important reservoir of that
American Society for Microbiology.
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8. Gamma Interferon Fails To Induce Expression of Indoleamine 2,3-Dioxygenase and Does Not Control the Growth of Chlamydophila abortus in BeWo Trophoblast Cells
The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.
American Society for Microbiology.
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9. Regulation of Indoleamine 2,3-Dioxygenase Expression in Simian Immunodeficiency Virus-Infected Monkey Brains†
The human immunodeficiency virus type 1-associated cognitive-motor disorder, including the AIDS dementia complex, is characterized by brain functional abnormalities that are associated with injury initiated by viral infection of the brain. Indoleamine 2,3-dioxygenase (IDO), the first and rate-limiting enzyme in tryptophan catabolism in extrahepatic tissues,
American Society for Microbiology.
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10. Inhibition of Chlamydia pneumoniae Replication in Human Aortic Smooth Muscle Cells by Gamma Interferon-Induced Indoleamine 2,3-Dioxygenase Activity
Infection with Chlamydia pneumoniae, a human respiratory pathogen, has been implicated as a potential risk factor in atherosclerosis, possibly because the pathogen can exist in a persistent form similar to that described for Chlamydia trachomatis. The present study investigated whether gamma interferon (IFN-γ) can induce indoleamine 2,3-dioxygenase (IDO) ac
American Society for Microbiology.
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11. Establishment of an antitoxoplasma state by stable expression of mouse indoleamine 2,3-dioxygenase.
Indoleamine 2,3-dioxygenase (IDO), a tryptophan-degrading enzyme, is inducible by various interferons (IFNs). IDO-mediated tryptophan degradation, but not the formation of IDO-catalyzed tryptophan metabolites, has been suggested as a mechanism for the antiparasitic action of IFN-gamma. To determine whether the IFN-gamma-induced IDO alone is sufficient for es
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12. The signal transduction mechanism responsible for gamma interferon-induced indoleamine 2,3-dioxygenase gene expression.
We examined the signal transduction mechanism responsible for the gamma interferon-induced indoleamine 2,3-dioxygenase (IDO) gene expression in a human monocytic cell line, THP-1. Our results suggest that gamma interferon-induced activation of protein tyrosine kinase is a prerequisite for gene expression and that activation of protein kinase C and another un